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The aim of this study is to investigate the targeting efficiency of FITC-SS31 to mitochondria in both normal and H2O2-induced oxidative damaged 661W cells, characterizing the properties of FITC-SS31 in the biological assays. The purity and molecular weight of FITC-SS31 were identified using HPLC and MS. MTT …

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4.1.1. SS-31 and AKI. Using an IR kidney injury model, Szeto et al. found that SS-31 reduced Scr levels, increased creatinine clearance, reduced tubular necrosis and apoptosis, and preserved brush border structure in a group of experimental rats at both 30 and 45 min following bilateral renal blood flow blockade and that it showed a significant …

(NOTE: If you aren't familiar with why mitochondrial health is important and all the things you can do to optimize it, read this article firstbefore continuing) SS-31 (a.k.a. Elampretide, Bendavia, MPT-141)is a synthetic … See more

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The Sczeto-Schiller peptide (SS-31), also known as Elamipretide, is an aromatic synthetic tetrapeptide that is primarily aimed at correcting mitochondrial …

(12) Jia, Yan-Li, et al. "SS31, a Small Molecule Antioxidant Peptide, Attenuates β-Amyloid Elevation, Mitochondrial/Synaptic …

Researcher reported that SS31 is essential in resisting hippocampal neuron withering by downregulating Bax gene and protein expression and upregulating Bcl-2 …

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SS31, and plasma and brain levels in wild-type (WT) mice. To determine whether SS31 crosses the blood brain barrier and reaches mitochondria, using intraperitoneal injections we administered SS31 (5 mg/kg body weight) twice a week for 6 weeks in a 12-month-old C57BL6 mice (n = 6).PBS-treated WT mice (n = 5) served as …

The protective effects of SS31 have been reported in several diseases, such as ischemic brain injury, acute kidney injury (AKI), diabetes mellitus and myocardial ischemia-reperfusion (IR) injury . SS31 has been shown to prevent IR injury by reducing mitochondrial dysfunction and oxidative stress . Surprisingly, the therapeutic role of …

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Thus, our study aimed to investigate the neuroprotective effects of SS31 by reversing mitochondrial dysfunction in EBI following SAH, via activating the Nrf2 signaling …

To assess the mitochondrial ROS decrease in SC-TK-SS31, HK-2 were seeded into 12-well plates and incubated with H 2 O 2 (500 μM) and different samples [SS31, C-TK-SS31, SC-NO-SS31, and SC-TK-SS31 at a concentration of SS31 (20 μg/ml)] for 24 hours. After washing with PBS three times, HK-2 cells were incubated with MitoSOX Red …

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By this mechanism, SS31 may have directly reduced sepsis-induced diaphragm damage in the current study. SS31 has, however, additional effects to reduce cytokine levels, inflammatory signaling pathways, mitochondrial dynamics (fission and fusion), and apoptotic pathway activation (24, 50). It is also possible, therefore, that these …

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